GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4420500 | 1 | rs4420500 | chr15:78962964 | CHRNB4 | chr15:78916636-78952874:- | 0.19 | 3.52 | 0.00047 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs4422476 | 1 | rs4422476 | chr4:118651823 | NDST3 | chr4:118954773-119179786:+ | -0.25 | -4.79 | 2.27E-6 | Neutrophil count |
| THCA | cis | rs442309 | 1 | rs442309 | chr10:64490495 | ADO | chr10:64564516-64568238:+ | -0.26 | -5.32 | 1.61E-7 | Vogt-Koyanagi-Harada syndrome |
| THCA | cis | rs10935120 | 1 | rs4423809 | chr3:134300107 | ANAPC13 | chr3:134196547-134204865:- | -0.37 | -11.34 | 1.51E-26 | Height |
| THCA | cis | rs10935120 | 1 | rs4423809 | chr3:134300107 | CEP63 | chr3:134204575-134293852:+ | -0.3 | -6.49 | 2.16E-10 | Height |
| THCA | cis | rs3745672 | 1 | rs442446 | chr19:12110074 | ZNF763 | chr19:12035900-12091196:+ | -0.32 | -3.88 | 0.000118 | Multiple sclerosis |
| THCA | cis | rs4265793 | 1 | rs4426336 | chr16:19027262 | COQ7 | chr16:19078927-19091350:+ | -0.29 | -3.91 | 0.000105 | Response to angiotensin II receptor blocker therapy |
| THCA | cis | rs6447650 | 1 | rs4428327 | chr4:40380204 | CHRNA9 | chr4:40337469-40356973:+ | -0.32 | -3.37 | 0.000803 | Body mass index (change over time) |
| THCA | cis | rs7029536 | 1 | rs4431687 | chr9:130111697 | RPL12 | chr9:130209955-130213684:- | 0.12 | 3.63 | 0.000312 | Metabolite levels (HVA) |
| THCA | cis | rs7029536 | 1 | rs4431687 | chr9:130111697 | SLC2A8 | chr9:130159465-130170161:+ | -0.13 | -3.42 | 0.000684 | Metabolite levels (HVA) |
| THCA | cis | rs935334 | 1 | rs4442739 | chr14:76647645 | ESRRB | chr14:76837690-76968178:+ | 0.26 | 4.3 | 2.09E-5 | Blood pressure |
| THCA | cis | rs4443100 | 1 | rs4443100 | chr22:23372864 | BCR | chr22:23522552-23660223:+ | 0.19 | 3.76 | 0.000193 | Serum parathyroid hormone levels |
| THCA | cis | rs4950322 | 1 | rs4448568 | chr1:146849017 | FMO5 | chr1:146655885-146697230:- | 0.26 | 4.14 | 4.16E-5 | Protein quantitative trait loci |
| THCA | cis | rs438034 | 1 | rs444971 | chr1:214831429 | KCNK2 | chr1:215178885-215410435:+ | 0.16 | 3.38 | 0.000771 | Response to antineoplastic agents |
| THCA | cis | rs1075232 | 1 | rs4450360 | chr15:31682030 | FAM7A2 | chr15:30864758-30892900:+ | -0.52 | -4.56 | 6.62E-6 | Survival in colorectal cancer (non-distant metastatic) |